Burroughs Wellcome Fund, Contribution of suprachiasmatic nuclear serotonin to the positive feedback effects of ovarian steroids on luteinizing hormone secretion (July-August 1983) $3,950.  To work with Dr. Catherine A. Wilson, Department of OB/GYN, St. Georges Hospital Medical School, University of London, England.

American Federation for Aging Research (AFAR),        A Pacemaker for Aging in the Female Reproductive System (Jan-Dec 1984) $12,804 (Principal Investigator).

Local Competition:

11/3/80            New Faculty Grant - Serotonin and control of biologic time structure by the suprachiasmatic nuclei: Role in aging of the female reproductive system, $18,600.

1/2/81              Major Research Equipment Grant - Dynamics of  Serotonin metabolism in the suprachiasmatic nuclei: Influence on female reproductive dysfunction in aging rats, $13,600.

2/4/81              Biomedical Research Support Grant, $3,350 - Role of serotonin in development of pituitary and mammary tumors in aging rats.

5/4/81               McDowell Cancer Network Grant, $2,300 - Role of serotonin in development of pituitary and mammary tumors in aging rats.

Completed (at other universities):

1978-1980         NIH Postdoctoral Research Grant F32 AG 05068 

1977-1978         Public Health Service Postdoctoral Training       Grant T32 AG 00029

1973-1976         USDA-ARS Cooperative Research Agreement with Clemson University, Contract #12-2427001

1973-1975         Clemson University Faculty Research Grant ($12,500).

TEACHING EXPERIENCE:

University of Kentucky Medical Center: 

Department of Anatomy

(1)  ANA 516 (Anatomy of the Nervous System: Neuroanatomy)

(2)  ANA 529 (Concepts in Morphology)

(3)  ANA 634 (Advanced Endocrinology)

Sanders-Brown Research Center on Aging

(1)  PGY 630 (Special Topics in Physiology/Biology of Aging

(2)  PCL 644 (Neuropharmacology)

University of California, Berkeley:

Department of Anatomy/Physiology 

(1)  Pharmacology 281 (Physiological Action of Drugs)

(2)  Physiology 153 (Physiology of the Aging Process)

(3)  Physiology 152 (Physiology of Human Development)

Clemson University, South Carolina:

Department of Zoology

(1)  General Zoology

(2)  General Biology

(3)  Vertebrate Physiology

(4)  General and Comparative Endocrinology

(5)  Comparative Physiology

(6)  Cell Physiology and Anatomy and Physiology 

UNIVERSITY SERVICE:

Medical College of Pennsylvania:

(1)  Graduate faculty: appointed to full status 9/1/85

University of Kentucky Medical School:

(1)  Committee on Aging

(2)  Research Proposal Review Committee

(3)  Seminar Chairman, Department of Anatomy, 1981-1984

(4)  Graduate faculty; appointed to full status 10/6/80

Clemson University:

University Level:

(1)  Preprofessional Health Curricula Committee (member)

(2)  Laboratory Animal Welfare Committee (member) 

College Level:

(1)  Admissions and Scholarship Committee

(2)  Animal Physiology Program (Chairman) 

STUDENTS: 

Medical College of Pennsylvania and Smith Kline and French Laboratories; one graduate student (Ph.D.) and one postdoctoral fellow.  

University of Kentucky, one postdoctoral fellow (1982-1984). 1 graduate student (Ph.D.) 

Clemson University, seven students for the degree Master of Science 

PROFESSIONAL AFFILIATIONS (Elected full member status): 

• Society of Toxicology

• Endocrine Society

• American Association of Anatomists

• International Society for Neuroendocrinology

• Society of Sigma XI 

PROFESSIONAL LICENSES 

Registered Pharmacist; PS0010079; Florida

RESEARCH INTERESTS:

Role of the brain and endocrine system in organismal aging; Neuropharmacology and reproductive endocrinology; Neuropeptides & biogenic amines

PATENTS:

Patent Number U.S.S.N.                                  Title

   898,523                                          Treatment of Hyperprolactinemia

   905,760                                           Diagnostic Procedure for Evaluating Growth Hormone
                     Secretion Deficiency

SYMPOSIA ORGANIZED:  

1.      International Symposium on Growth Hormone II:  Basic and Clinical Aspects, Tarpon
  Springs, Florida, 1992 (Serono Symposia; Chairpersons, R. F. Walker, B.B. Bercu)

2.      International Symposium on Growth Hormone Releasing Secretagogues, St. Petersburg,
   Florida, 1994 (Serono Symposia; Chairpersons, R.F. Walker, B.B. Bercu)

3.      Workshop Conference on Growth Hormone Releasing Secretagogues, US Food and Drug
   Administration, Bethesda, Maryland, 1994 (Chairpersons, R.F. Walker, B.B. Bercu)

4.      Second International Symposium on Growth Hormone Releasing Secretagogues, Tampa,
   Florida, 1997 (Chairpersons, R.F. Walker, B.B. Bercu)

5.      International Symposium on Endocrine and Molecular Interventions in Aging, Tampa,
   Florida, 1998 (Chairpersons, R.F. Walker , B.B. Bercu)

6.      Forum on Drug and Hormone Interventions in Aging, Tampa, Florida 1998 (Chairpersons,
   R.F. Walker, B.B. Bercu)

7.      International Symposium on the Endocrinology of Aging, Tempe, Arizona, 1999 (Serono
   Symposia; Chairpersons, R.F. Walker , B.B. Bercu)

8.      Third International Symposium on Growth Hormone Secretagogues, Keystone, Colorado,
   2000 (Chairpersons, R.F. Walker, B.B. Bercu)

9.      Third International Symposium on the Endocrinology of Aging (Serono Symposia;
   October 17 – 20, 2001;  Clearwater, FL, Chairpersons, R.F. Walker, B.B. Bercu)

10.    Fourth International Symposium on Growth Hormone Secretagogues, November, 7- 11,
  2002; Clearwater, FL, Chairpersons, R.F. Walker, B.B. Bercu)

11.    3^rd World Congress on the Aging male; Is Aging a Disease?, Berlin, Germany, February 7-
  11, 2002 (Serono Symposia satellite meeting, R.F. Walker, Chairman)

 

SUMMARY OF EMPLOYMENT EXPERIENCE

1999 – present

CONSULTANT IN MEDICAL PHYSIOLOGY (Endocrinology/Pharmacology)

• Create clinical research programs for hormone replacement during aging.

• Function as liaison with the FDA to ensure compliance with federal guidelines for human subject research.

• Serve as regulatory officer and coordinator of client networks performing clinical trials, supervise CRA staff performing studies, statisticians performing data reduction and analysis, create reports to IRB and FDA as required, publish data in peer-reviewed journals, maintain portfolios for each drug in development.

1996 - 1999

DIRECTOR, Division of Pharmaceutical Studies, and General Manager, Clinical Alliance for Research Education & Service, Office of Research, University of South Florida, Tampa, FL

• Expand numbers of USF contracts from the pharmaceutical industry

• Enhance the economy of the State of Florida and the US in furthering the development of university-industry-government partnerships.

• Develop for USF CARES a solid reputation as a research contract organization that is capable of all levels of pharmaceutical drug/device development.   

1995 - 1999

DIRECTOR, Division of Compliance Services, University of South Florida, Office of Research,  Tampa, FL

• Develop, maintain and administer programs that assure compliance with federal and state guidelines related to the appropriate conduct of research.  

• Managerial responsibilities include institutional review board (IRB), institutional animal care and use committee (IACUC), radioactive drug research committee (RDRC), radiation safety program, biohazardous material control and diving safety programs. 

1991 - Present

RESEARCH PROFESSOR, Department of Pediatrics, and Department of Biochemistry and Molecular Biology, University of South Florida College of Medicine Tampa FL, and Division of Endocrinology, All Children's Hospital, St. Petersburg, FL 33706

• Perform basic research on neuroendocrine mechanisms of growth, development and aging.  Support and maintain that research from public and private granting agencies including the American Cancer Society, National Institutes of Health, Department of Defense, Pharmaceutical Industry (companies include Pfizer, Merck, Kaken/Wyeth Ayerst, SmithKline Beecham, Serono Intl., BioNebraska, Dainippon, etc.)

• Manage laboratory of endocrinology, insuring successful progression of goals and time tables, making administrative and managerial decisions regarding personnel commitments and expenditures, interpreting data, disseminating information at scientific meetings and other appropriate forums and being responsible for the prompt and accurate preparation of progress reports and publication of data in peer-reviewed journals.

• Teach and supervise post-doctoral fellows and research associates while executing studies, entering new information into the database, implementing new laboratory techniques, ordering supplies and maintaining supply records and radioisotope/narcotic licenses.

• Pharmacology Consultant; provide expertise pharmacology/toxicology/clinical issues to pharmaceutical companies relevant to development and registration of new products, ie. from IND through NDA. Act as liaison between sponsor and FDA during drug licensing process.  Provide expert opinions on drug-related issues involving legal disputes.

• Registered pharmacist; prepare and dispense medication pursuant to physicians orders for clinical studies

1985-1991

ASSOCIATE DIRECTOR, Department of Toxicology, SmithKline Beecham Pharmaceutical Company, King of Prussia, PA 19406

• Project representative, providing pharmacology/toxicology input to Project Teams for compounds in development.  Formulate pathology/toxicology element of the development plan.  Schedule and direct battery of toxicology studies in a timely fashion consistent with meeting deadlines for IND and NDA submissions.  Make presentations at FDA when needed to support progression of projects in clinical development.  Insure that toxicological studies are appropriate to support international registration of compounds in development.

• Study director, scheduling supervising and reporting results of general toxicology GLP and investigative studies.

• Manage Reproductive and Developmental Toxicology Division, insuring that schedules, designs and implementation of reproductive toxicological tests on compounds in development are in compliance with FDA Segment I, II and III GLP guidelines.

• Generate appropriate reports and manuscripts in conjunction with safety studies.

• Head, Neuroendocrine Laboratory for investigative toxicology/pharmacology studies.

• Miscellaneous:  Prepare section budget, supervise and evaluate employees, design and initiate basic research studies on pharmacological mechanisms of actions loci of toxicity involving compounds in development.

1985-1988

RESEARCH PROFESSOR, Department of Pharmacology, Medical College of Pennsylvania, Philadelphia, PA 19128

• Principal investigator on 3 federally funded research projects that focused upon neuropharmacology and neuroendocrinology of monoamines.

• Budgetary responsibilities for approximately 1 million dollars in grant funds.

• Oversee, train, evaluate professional and technical research staff on my projects.

• Write continuation and competing renewals for federal and local research grants.

RESEARCH PROFESSOR, Department of Obstetrics and Gynecology, Medical College of Pennsylvania, Philadelphia PA 19128

• Collaborative research with clinical faculty providing correlative data from basic sciences projects for analysis of human responses

1980 - 1985

ASSOCIATE PROFESSOR (with tenure), Department of Anatomy, University of Kentucky Medical Center, Lexington, KY 40536

• Teach neuroanatomy to medical and allied health students

• Serve on graduate faculty of College of medicine.

• Manage research programs, identify new sources of funding, expand support base from local and federal sources

• Publish reports in peer-reviewed journals and expand scientific reputation.

SENIOR SCIENTIST, Sanders-Brown Research Center on Aging, University of Kentucky Medical Center, Lexington, KY 40536

• Establish and expand public relations of the Aging Center with community physicians and lay persons.

• Develop research programs to probe neurological mechanisms of senescence.

• Present seminars and short courses on aging and its biological basis.

1977 - 1980

RESEARCH FELLOW, University of California, Department of Physiology/Anatomy, Berkeley, CA

• Basic research in neuropharmacology/neuroendocrinology

RESEARCH FELLOW, Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, NC

• Basic research in pharmacology of molecules affecting the reproductive system 

1972 - 1977

ASSISTANT PROFESSOR TO ASSOCIATE PROFESSOR (with tenure), Department of Biology, Clemson University, Clemson, SC

• Teach undergraduate and graduate courses in physiology/pharmacology

• Train graduate students

• Establish research program, acquire grants, develop teaching and research laboratories

• Participate in departmental and university service functions.

PUBLICATIONS: Peer-Reviewed Articles, Chapters and Books

2002                 Walker RF.  Is Aging a Disease?  A Review of the Serono Symposia Workshop held under the auspices of The 3^rd World Congress on the Aging Male February 9, 2002, Berlin Germany.  The Aging Male5:1-23

2002                 Walker RF.  Anti-Aging Medicine: Collecting Data or Collecting of Fees? Editorial. J
 Anti-Aging Med. 5(3):234-246

2002                 Bercu BB, Walker RF. Relative Values of Recombinant GH and GH Secretagogues in Clinical Practice.  The Endocrinologist 12(5):433-444.

2002                 Walker RF. Assessing Safety and Efficacy of Growth Hormone Replacement in Aging by Community Physicians. J Anti-Aging Med. 5(1): 41-55.

2002                 Walker, RF, Bercu BB.  Growth hormone therapy in aging:  Is aging a treatable disease?  J Anti-Aging Med 5(1):3-6.

2001                 Walker RF, Bercu BB.  Issues regarding the routine and long term use of growth hormone in anti-aging medicine: I.  J Anti-Aging Med 4(4):279-300

2001                 Bercu BB, Walker RF.  Preface to Winter 2001 and Spring 2002 Issues; Growth Hormone Therapy in Aging.  J Anti-Aging Med 4(4):273-277.

2001                 Bercu BB, Walker RF. Editors; Growth Hormone Therapy in Aging. J Anti-Aging Med 4(4)

2001                 Walker, RF.  Endocrinology of Aging (Book Review).  Journal of Anti-aging Medicine 4 (1):67-70

2001                 Bercu BB, Walker, RF. Editors; Growth Hormone Secretagogues. Endocrine Vol. 14 (1).

2000                Walker, RF, Bercu, BB.  International Symposium on the Endocrinology of Aging: A Serono Symposium (editorial), J. Anti-Aging Medicine 3(3):259-261               

2000                 Bercu BB, Walker, RF.  International Symposium on the Endocrinology of Aging:  A Serono Symposium (editorial), J. Anti-Aging Medicine 3(1):63-65                   

1999                 Walker, R.F., Bercu, B.B.  Use of growth hormone secretagogues for diagnosing and treating GH secretory deficiency in children and aging men.  In:  Dieguez, C., Ghigo, E., Boghen, M, Casanueva, F.F. (editors), Growth Hormone Secretagogues: Basic Finding and Clinical Implications, Elsevier Science B.V., Amsterdam, The Netherlands.

1998                 Bercu, B.B., Walker, R.F.  Report on international symposium on endocrine and molecular interventions in aging.  J.  Anti-Aging Med 1:143-144

1998                 Walker, R.F., Bercu B.B. Aging Interventions: The Forest from the Trees (editorial), J. Anti-Aging Med 1:167 - 168

1998                 Walker, R.F., Bercu, B.B.  Effectiveness of growth hormone (GH) secretagogues for diagnosing and treating GH secretory deficiency in aging men.  J. Anti-Aging Med 1:219 - 225 .

1998                 Walker, R.F., Bercu, B.B.  (guest editors).  Special Papers on Endocrine Aspects of Aging.  J. Anti-Aging Med: 1(3)

1998                 Bercu, B.B., Walker, R.F.  (editors) Growth Hormone Secretagogues in Clinical Practice, Marcel Dekker, New York, NY.

1998                 Bercu, B.B., Walker, R.F.  Evaluation of pituitary function using growth hormone secretagogues.  In:  Bercu, B.B., Walker, R.F.  Growth Hormone Secretagogues in Clinical Practice.  Marcel Dekker, New York, NY, pp. 187-207.

1997                 Bercu, B. B., Walker, R. F.  Growth hormone secretagogues in children with altered growth.  Acta Paediatr Suppl 423:102-106.

1997                 Walker, R. F., Bercu B. B.  Effects of a growth hormone releasing peptide-like nonpeptidyl growth hormone secretagogue on physiology and function in aged rats. In: Bercu BB, Walker, RF (eds) Growth Hormone Secretagogues II. Marcel Dekker, New York N.Y. pp 1187 - 208.

1997                Bercu, B. B., Walker, R. F. Evaluation of pituitary function using growth hormone secretagogues. In: Bercu BB, Walker RF (eds) Growth Hormone Secretagogues in Clinical Practice. Marcel Dekker, New York, NY pp. 285-303.

1997               Bercu, B.B., Walker, R.F.  (Editors). Growth Hormone Secretagogues in Clinical Practice. Marcel Dekker, New York N.Y.

1997                 Bercu, B.B., Walker, R.F.  Novel growth hormone secretagogues.  The Endocrinologist 7: 51-64

1996              Bercu, B.B., Walker, R.F. (edited book) Serono Symposium Growth Hormone Secretagogues; with 138 figures.  Springer-Verlag, New York, pp 253-287.

1996                 Walker, R.F., Bercu, B.B.  Animal models for evaluating xenobiotic growth hormone growth hormone secretagogue activity. In: Serono Symposium Growth Hormone Secretagogues, B.B. Bercu and R.F. Walker, (eds) Springer-Verlag, New York, pp 253-287.

1996                Bercu, B.B., Walker, R.F.  A diagnostic test employing growth hormone secretagogues for evaluating pituitary function in the elderly.  In: Serono Symposium Growth Hormone Secretagogues, B.B. Bercu and R.F. Walker, (eds) Springer-Verlag, New York, pp 289-305.

1996                Bercu, B.B., Walker, R.F.  Evaluation of pituitary function in children using growth hormone secretagogues. J Ped Endo Metab 9:325-332             

1995                Bercu, B.B., Heinze, H.J., Walker, R.F.  Use of growth hormone in non-growth-hormone-deficient children: Physiologic, pharmacologic and ethical issues.  In: Serono Symposium GHRH, GH and IGF-1, Basic and Clinical Advances, M.R. Blackman, J. Roth, S.M. Harman and J.R. Shapiro (eds). Springer-Verlag, New York, pp 143-168.

1995                 Walker, R.F.  Neuroendocrine correlates of female reproductive senescence.  In: The Menopause: Comprehensive Management, 3rd Edition.  B. A. Eskin (ed). McGraw Hill, Inc. New York, pp 229-256.

1994                 Walker, R.F., Yang, S‑W., Masuda, R., Hu, C‑S., Bercu, B.B. Effects of growth  hormone releasing peptides on stimulated growth hormone secretion in old rats In: Growth  Hormone II: Basic and Clinical Aspects. Bercu, B.B., Walker, R. F. (eds). Springer‑Verlag Inc:  New York.

1994                 Walker, R.F., Engleman R.W., Pross, S. and Bercu B. B. Effects of growth hormone secretagogues on age-related changes in the rat immune system.  Endocrine 2: 857-862.

1994                 Walker R.F., Eichler DC. and Bercu B.B.  Inadequate pituitary stimulation: a possible cause of growth hormone insufficiency and hyperprolactinemia in aged rat. Endocrine 2:633-638.

1994                 Walker R. F., Ness G.C., Zhihong Z., Bercu B.B.  Effects of stimulated growth hormone secretion on age-related changes in plasma cholesterol and hepatic low density lipoprotein messenger RNA concentrations. Mechanisms of Aging and Development: 75:215-226.

1994               Bercu B.B., Walker R.F. (Eds) Growth Hormone II: Basic and Clinical Aspects. Springer-Verlag Inc. New York.

1992                 Bercu, B.B., Yang, S-W., Masuda R. and Walker, R.F. Role of selected endogenous peptides in growth hormone releasing hexapeptide (GHRP-6) activity: Analysis of GHRH, TRH and GnRH.  Endocrinology 130:2579-2586.

1992                 Walker, R.F. and Cooper, R.L. Toxic effects of xenobiotics on the pituitary gland. In: Endocrine Toxicology, edited by C. Atterwill and J. Flack, Cambridge University Press, Cambridge, pp 51-82.

1992                Bercu, B.B., Yang, S-W., Masuda, R., Hu, C-S, and Walker, R.F.  Effects of co-administered growth hormone (GH) releasing hormone and GH releasing hexapeptide on maladaptive aspects of obesity in female Zucker rats.  Endocrinology 131:2800-2804.

1991                 Walker, R.F. and Fishman, B.E. Influence of age on neuro-toxicity. In: Aging and Environmental Toxicology, R. L. Cooper, J.M. Goldman and T.J. Harbin (eds.), John Hopkins University Press, Baltimore, pp 211-231.

1991                Nelson, A.H., Walker, R.F., Codd, E.E. and Barone F.C.  Intranasal activity of the growth hormone releasing peptide His-D-Trp-Ala-Trp-D-Phe-Lys-NH₂ in conscious dogs.  Life Sciences 48:2283-2288.

1991                Bercu, B.B., Weideman, C.A. and Walker, R.F.  Sex differences in growth hormone secretion by rats administered growth hormone releasing hexapeptide (GHRP-6).  Endocrinology 129:2592-2598.

1991                 Walker, R.F., Yang, S-W. and Bercu, B.B.  Robust GH secretion in aging female rats coadministered growth hormone releasing hormone (GHRH) and GH releasing hexapeptide (GHRP-6). Life Sciences 49:1499-1504.

1990                Codd, E.E., Aloyo, V.J. and Walker, R.F. A non-opioid pattern characterizes inhibition of growth hormone releasing peptide binding by dynorphin-related peptides. Neuropeptides 15:133-137.

1990                 Walker, R.F. and Cooper R.L. Endocrine physiology and reproductive senescence. In: B.A. Eskin (ed.) Menopause: Comprehensive Management, 3rd Ed., Yearbook Medical Publications, New York,  pp 211-270.

1990                 Walker, R.F., Codd, E.E., Barone, F.C., Nelson, A.H., Goodwin, T and Campbell, S.A. Oral activity of the growth hormone releasing peptide His-D-Trp-Ala-Trp-D-Phe-Lys-NH₂in rats, dogs and monkeys.  Life Sciences 47:29-36.  

1989                 Walker, R.F. and Aloyo, V.J. Modulation of norepinephrine and serotonin release by ACTH and aMSH in the pineal gland. Neuroendocrinol. 43:12-20.

1989                 Huffman, W.F., Callahan, J.F., Codd, E.E., Eggleston, B.S., Lemieux, C., Newlander, K.A., Schiller, P.W., Takata, D.T., and Walker, R.F. Mimics of secondary structural elements of peptides and proteins. In: Synthetic Peptides: Approaches to Biological Problems. UCLA Symposium on Molecular and Cellular Biology, (Ed. J.Tam and T.Kaiser), Alan R. Liss, Inc. pp 257-266.  

1989                 Bryan, W.M., Callahan, J.F., Codd, E.E., Lemieux, C. Moore, M.L., Schiller, P.W., Walker, R.F., Huffman, W.F.Cyclic enkephalin analogs containing a-amino-7-mercapto-4,7-cyclopentamethylenepropionic acid at positions two or five. J. Med. Chem. 32:303-304.  

1989               Codd, E.E., Shu, A.Y.L., Walker, R.F. Binding of the growth hormone releasing hexapeptide, SK&F 110679 to specific hypothalamic and pituitary sites. Neuropharmacology 28:1139-1144.  

1989                 Walker, R.F., Guerriero, F.J., Toscano, T.V. and Weideman, C.A. Relative cerebellar weight: A potential indicator of developmental neurotoxicity. Neurotoxicology and Teratology ll(3):251-255.  

1989                 Wier, P.J., Guerriero, F.J., and Walker, R.F. Implementation of a primary screen for developmental toxicity. Fund Appl. Toxicol. 13:118-136. 

1989                 Aloyo, V.J., Lewis, M.E. and Walker, R.F. Opioid peptide mRNAs in the rat pineal. In:  International Narcotic Research Conference (INRC), R. Wuirion, K. Jhamanda and C. Gianoulakis (eds.) Alan R. Liss, New York, pp 235-238.

1988                 Huffman, W.F., Callahan, J.F., Eggleston, B.S., Newlander, K.S., Takata, D.T., Codd, E.E., Walker, R.F. Schiller, P.W., Lemieux, C., Wire, W.S., Burks, T.F. Reverse turn mimics. In:  Peptides: Chemistry and Biology: Proceedings of the tenth peptide symposium, (Ed. G.R. Marshall) ESCOM, Leiden, pp 105-108.

1988                 Jimenez, A. and Walker, R. F. Influence of serotonin (5HT) synthesis on circadian patterns of 5HT accumulation in the rat hypothalamus during development. Int. J. Devel. Neurosci. 6:203-209. 

1988                 Aloyo, V.J. and Walker, R.F. Alpha-adrenergic control of  serotonin release from rat pineal glands.   Neuroendorinology 48:61-66.  

1988                 Eskin, B.A., Trivedi, R.A., Weiderman, C.A. and Walker, R.F. Feedback disturbances revealed by analysis of serum reproductive hormones in women during aging. Am J. Gyn. Health 2:9-15 (Dec). 

1988                 Walker, R. F., Weideman, C.A. and Wheeldon, E. B. Reduced disease in aged rats treated chronically with ibopamine, a catecholaminergic drug. Neurobiol. Aging 9:291-301. 

1988                 Codd, E.E., Yellin, T. and Walker, R.F. Binding of growth hormone releasing hormones and enkephalin-deprived growth hormone releasing peptides to mu and delta opioid receptors in rat forebrain. Neuropharmacology 27:1019-1025.

1988                Walker, R.F., Schwartz, L.W. and Manson, J.M.  Ovarian effects of an antiinflammatory-immunomodulatory drug in the rat.  Toxicol. Appl. Pharm. 94(2):266-275. 

1988                 Walker, R.F., Schwartz, L.W. and Torphy, T.J., Newton, J.F. and Manson, J.M. Ovarian effects of SK&F 86002-A2 in the rat: site of action. Toxicol. Appl. Pharm 94(2):276-275.

1988                 Walker, R.F., Guerriero, F. and Wier, P. Design of a primary screen for developmental neurotoxins. Toxicol. Indust. Health 5:231-245.

1988                 Jackson, J.C., Walker, R.F., Brooks, W.H., and Roszman, T.L. Specific uptake of serotonin by murine macrophages.Life Sciences 42:1641-1650.

1988                 Codd, E.E., McAllister, T.W. and Walker, R.F. Factors affecting serotonin uptake into human platelets. Psychopharmacology 95:180-184.

1987                 Aloyo, V.J. and Walker, R.F.  Noradrenergic stimulation of serotonin release from rat pineal glands, in vitro. Journal of Endocrinology 114:3-9.

1987                 Walker, R.F. and Aloyo, V.J.  Molecular mechanisms controlling morepinephrine-mediated release of serotonin from rat pineal glands. In: Y.H. Ehrlich (eds.)  Molecular Mechanisms of Neuronal Responsivity, Advances in Experimental Medicine and Biology 221:223-236.

1987                 Codd, E.E. and Walker, R.F. Mu/delta opioid site selectively of some antidepressants. In: J. Holaday, A. Herz and P.Y. Law (eds.) NIDA Research Monograph, Progress in Opioid Research 75:351-354.

 1987               Navarro, H.A., Aloyo, V.J., Rush, M.E. and Walker, R.F. Serotonin pharmacodynamics in hypothalamic tissues from young and old female rats. Brain Research 421:291-296.

1986                Walker, R.F., Sparks, D.L., Slevin, J. and Rush, M.E. Temporal effects of norepinephrine on pineal serotonin, in vitro. J. Pineal Res. 3:30-40.

1986                 Walker, R.F. and Cooper, R.L. Endocrine physiology and reproductive senescence. In: B.A. Eskin (ed.) Menopause: Comprehensive Management, 2nd Ed., Yearbook Medical Publications, New York pp. 209-235.

1986                 Walker, R.F.  Age factors potentiating drug toxicity in the reproductive axis.  Environ. Health Persp. 70:185-191.

1985               Walker, R.F.and Jimenez, A. The serotoninergic system. In; Handbook of Methodologies for the Study of Neuro-endocrine System (R. W. Steger and A. Johns, eds.)    CRC Press, Inc., Boca Raton pp.109-154.

1985                 Walker, R.F. and Cooper, R.L. Synergistic effects of estrogen and serotonin-receptor agonists on the development of pituitary tumors in aging rats. Neurobiology of Aging 6:107-111.

1985                 Goldman, J.M., Walker, R.F. and Cooper, R.L. Aging in the rat hypothalamic-pituitary-ovarian axis: The involvement of biogenic amines in the loss of reproductive cyclicity. In: H. Parvez and D. Gupta (eds.) Neuroendo-crinology of Hormone Transmitter Interaction, V.N.U. Science Press, Utrecht pp 127-152.

1985                Jackson, J.C., Cross, R.J., Walker, R.F., Brooks, W.H., Markesbery, W.M. and Roszman, T.L. Neuroimmunomodulation: Influence of serotonin on the immune response. Immunology 54:505-512.

1985                 Humphries, L.L., Shirley, P., Codd, E.E. and Walker, R.F.Daily patterns of serotonin uptake in platelets from psychiatric patients and control volunteers. Biol Psychiatry 20:1073-1081.

1985                 Walker, R.F. and Aloyo, V.J. Norepinephrine stimulates serotonin secretion from rat pineal glands, in vitro. Brain Res. 343:188-189.

1985                 Walker, R.F. and Codd, E.E. Neuroimmunomodulatory interactions of norepinephrine and serotonin, J. Neuroimmunology 10:41-48.

1984                Walker R.F and Jimenez, A. Quantitative relationship between light intensity and LH surges in ovariectomized rats treated with estrogen. Biol. Reprod. 30:87-92.

1984                Walker R.F. Impact of age-related changes in serotonin and norepinephrine metabolism on reproductive function in female rats.  An analytical review. Neurobiol.Aging 5:121-139.

1983                 Walker, R.F. and Cooper, R.L. (Editors) Experimental and Clinical Interventions in Aging: Biomedical Explorations in Aging, Marcel Dekker, New York (November).

1983                Walker, R.F.  Animal models for aging research. In Experimental and Clinical Interventions in Aging. (R.F.Walker and R.L. Cooper, eds.) Marcel Dekker, New York pp 67-84.

1983                 Walker, R.F. Serotonin-reinstatement of LH surges after positive feedback is lost in ovariectomized rats bearing subcutaneous estrogen-containing capsules. Journal of Endocrinology 98:7-17.

1983                 Walker, R.F. Quantatitive and temporal aspects of serotonin's facilitatory effect on LH surges in ovariectomized, estrogen-primed rats. Neuroendocrinology 36:468-474.

1983                 Walker, R.F. Reinstatement of cyclic reproductive function in aging female rats. In: Aging and Recovery of Function (S.Scheff, ed.) Plenum Press, New York 1983 Cooper, R.F. and Walker, R.F. Radioenzymatic assays for neurotransmitters. In:  Methods of Enzymology: Neuro-endocrine Peptides (P.M. Conn, ed.) Academic Press, New York, pp. 483-493

1983                Walker, R.F. and Wilson, C.A. Changes in hypothalamic serotonin associated with amplication of LH surges by progesterone in rats.  Neuroendocrinology 37:200-205.

1983                Walker, R.F., Friedman, D.W. and Jimenez, A. A modified enzymatic-isotopic microassay for serotonin (5HT) using 5HT-N-acetyltransferase partially purified from Drosophila. Life Sciences 33:1915-1924.

1982                 Walker, R.F. and Timiras, P.S. Pacemaker insufficiency and the onset of aging. In: Cellular Pacemakers II (D. Carpenter, ed.) Wiley Interscience, New York, pp. 396-425.

1982                 Walker, R.F., McCamant, S., and Timiras, P.S. Melatonin and the influence of the pineal gland on timing of the LH surge in rats.  Neuroendocrinology 35:37-42.

1982                 Walker, R.F. Reinstatement of LH surges by serotonin  neuroleptics in aging, constant estrus rats. Neurobiology of Aging 3:253-257.

1982                 Walker, R.F., Melatonin: serotonin interactions during termination of the LH surge in rats. In: The Pineal and Its Hormones (R. Reiter, ed.) Alan R. Liss, Inc., New York, pp 167-176.

1981                 Walker, R.F. Reproductive senescence and the dynamics of hypothalamic serotonin metabolism in the female rat. In: Brain Neurotransmitters and Receptors in Aging and Age Related Disorders (T. Samorajski, S.J. Enna, and B. Beer,eds.) Raven Press, New York, pp. 95-105.

1981                Walker, R.F. and Timiras, P.S. Serotonin in development of cyclic reproductive function. In: Serotonin: Current Aspects of Neurochemistry and Function, Adv. Exp. Biol. Med. 133 (B. Haber, S. Gabay, M.R. Issidorides and S.G.A.Alivisatos, eds.) Plenum Press, New York, pp. 525-542.

1980                Walker, R.F., Cooper, R.L. and Timiras, P.S. Constant estrus: Role of rostal hypothalmic monoamines in development of reproductive dysfunction in aging rats.  Endocrinology 107(1):249-255.

1980                 Walker, R.F. and Timiras, P.S. Loss of serotonin circadian rhythms in the pineal gland of androgenized female rats. Neuroendocrinology 31:265-269.

1980                Eisenberg, E. and Walker, R.F. Physiological aspects of menopause: Clinical and experimental studies. In:Hormones in Development and Aging (P.S. Timiras and A.Vernadakis, eds.) Spectrum Publ. New York, pp 517-537.

1980                 Walker, R.F. Serotonin circadian rhythm as a pacemaker for reproductive cycles in the female rat. In: Prog. Psychoneuroendocrinology (F. Brambilla, G. Racagni, and D. deWied, eds.) Elsevier/ North Holland, Amsterdam, pp. 591-600.

1980                Timiras, P.S., Segall, P.E. and Walker, R.F.  Psychological aging in the central nervous system: Perspectives on "interventive" gerontology. In: Aging- Its Chemistry. Proc. 3rd Arnold O. Beckman Conf. in Clin. Chem. (A. Dietz,ed.), Am Assn. Clin. Chem., Washington, DC pp.46-63.

1980                Walker, R.F. Serotonin neuroleptics change patterns of preovulatory secretion of luteinizing hormone in rats. Life Sciences 27(12):1063-1068.

1980                 Cooper, R.L., Conn, M.P. and Walker, R.F. Characterization of the LH surge in middle-aged female rats. Biol. Reprod. 23:611-615.

1979                Cooper, R.L., Brandt, S.J., Linnoila, M. and Walker R.F. Induced ovulation in aged female rats by L-Dopa implants into the medial preoptic area. Neuroendocrinol, 28:234-240.

1979                 Cooper, R.L. and Walker, R.F. Potential therapeutic consequences of age-dependent changes in brain physiology. In: Experimental and Clinical Aspects of Pharmacological Intervention in the CNS Aging Process, Interdiscipl. Topics Gerontol. Vol. 14 (W.Meier-Ruge & H. von Hahn, eds.) S. Karger, Basel, pp. 54-76.

1978                Bethea, C.L. and Walker, R.F. Parietal eye-pineal gland interactions in the lizard, Sceloporus occidentalis. J. Herpetology 12(1):83-87.

1978                Walker, R.F., McMahon, K.M. and Pivorun, E.B. Pineal gland structure and metabolism as affected by age and hypocaloric diet. Exp. Gerontol. 13:91-99.

1978                 Bethea, C.L. and Walker, R.F. Age-related changes in reproductive hormones and in Leydig cell responsivity in the male Fisher 344 rat. J. Gerontol. 34:21-27.

1978                Walker, R.F. and Cooper, R.L. Influence of the thyroid gland on aging in the reproductive system of the female rat. Adv.Exp.Biol.Med. 113:111-126.

1977                Lee, F., Walker, R.F. and Hatcher, J.S. Fine particles of cotton dust influence histamine release. Int. J. Occ. Health & Safety  46(4):42-45.

1977                Walker, R.F. and Bethea, C.L. Gonadal function in underfed rats: I. Effect of pineal gland and constant light on  maturation and fecundity. Biol. Reprod. 17:623-629.

1977                Walker, R.F., and Frawley, L.S. Gonadal function in underfed rats. II. Effect of estrogen on plasma gonado-tropins after pinealectomy or constant light exposure. Biol. Reprod. 17:630-634.

1975                Walker, R.F., Eidson, G.W. and Hatcher, J.D. Comparative responses of pulmonary leukocytes to cotton dust inhalation.  Laboratory Invest. 33:28-34.

1974                Frawley, L.S. and Walker, R.F. The effect of light on thyroid activity in bullfrog tadpoles. Gen. Comp. Endocrinol. 24:83-86.

1973                Walker, R.F. Influence of subtrachael fat body depletion on thyroid function in the desert iguana. Comp. Biochem. Physiol. 44A:911-917.

1973                Walker, R.F. Temperature effects on thyroid function in the lizard, Sceloporus cyanogenys. Gen. Comp. Endocrinol. 20(1):137-143.

1971               Walker, R.F., and Thronebury, B. Lipid content of Verticillium albo-atrum. Phytochemistry 10:2979-2982.

1970               Walker, R.F. and Whitford, S. Soil water absorption capabilities in selected anuran species. Herpetologica 26:411-418.

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