|
RICHARD FRANCIS WALKER, Ph.D., R.Ph.
Curriculum Vitae
| EDUCATION |
Postdoctoral
(Neuropharmacology and neuroendocrinology) |
Department of Physiology-Anatomy
University of California, Berkeley
Supported by NIH Postdoctoral Fellowship #F32
AG05068 with Dr. Paola S. Timiras |
Postdoctoral
(Neuroendocrinology) |
Center for the Study of Aging and Human
Development
Duke University Medical Center
Durham, North Carolina
Supported by NIH Postdoctoral Training Grant
#T32 AG00029 with Dr. Ralph L. Cooper |
Doctor of Philosophy
(Physiology/endocrinology) |
Department of Physiology
Rutgers University
New Brunswick, New Jersey
Advisor: Dr. Daniel C. Wilhoft
Dissertation: Environmental Influences on Thyroid Function in Heliothermic Vertebrates |
| Master of Science (Biochemistry)
|
Department of Biology
New Mexico State University
Las Cruces, New Mexico
Thesis Advisor: Dr. Glyn Thronebury
Thesis: Lipids of Verticillium albo atrum |
| Bachelor of Science (Pharmacy) |
Rutgers University
Newark, New Jersey |
| |
| EMPLOYMENT AND PROFESSIONAL EXPERIENCE |
| 1999-present |
Consultant in Medical Physiology (Endocrinology)
Paradox Regulatory and Scientific Services, Inc.
Harbor Drive
Indian Rocks Beach, Florida |
| 1996-1999 |
Director
Division of Pharmaceutical Studies
Clinical Alliance for Research Education & Service
Office of Research
University of South Florida
Tampa, Florida |
| 1995-1999 |
Director
Division of Compliance Services
Office of Research
University of South Florida
Tampa, Florida |
| 1991-present |
Research Professor
Division of Endocrinology
Department of Pediatrics & Department of Biochemistry and Molecular Biology
Univ. South Florida College of Medicine
Tampa, Florida |
| 1985-1991 |
Associate Director
Department of Toxicology
Smith Kline & French Laboratories
King of Prussia, Pennsylvania |
| 1985-1991 |
Research Professor
Division of Psychoneuropharmacology
Department Pharmacology
Medical College of Pennsylvania
Philadelphia, Pennsylvania |
| 1980-1985 |
Associate Professor (tenured)
Department of Anatomy
University of Kentucky Medical Center
Lexington, Kentucky |
| 1980-1985 |
Research Scientist
Sanders-Brown Research Center on Aging
University of Kentucky
Lexington, Kentucky |
| 1978-1980 |
Postdoctoral Research Fellow
Department of Physiology-Anatomy
University of California
Berkeley, California |
| 1977-1978 |
Postdoctoral Research Fellow
Center for Study of Aging and Human
Development
Duke University Medical Center
Durham, North Carolina |
| 1972-1977 |
Assistant Professor (tenured)
Department of Zoology
Clemson University
Clemson, South Carolina
Tenure awarded June, 1975 |
| |
| RESEARCH GRANTS, CONTRACTS AND AWARDS |
| Funded at the University of South Florida College of Medicine |
| 1994-1995 |
Wyeth Ayerst Pharmaceutical Company, Diagnostic Testing of Growth Hormone (GH) Secretory Abnormalities in Short Children Using GRF
1-29 and GH Secretagogues, $78,000 (Co-investigator with B. B. Bercu) |
| 1993-1994 |
Merck Research Laboratories, Effects of a Novel GH Secretagogue on Physical Performance in Aged Rats, $72,000 (Principal Investigator) |
| Funded at the Medical College of Pennsylvania, National Competition |
| 1985-1988 |
NIH RO1 NS 22065, Neural Modulation of Platelet 5HT Pharmacodynamics, $192,159 (Principal Investigator) |
| 1985-1988 |
US Air Force Office of Scientific Research Molecular Aspects of Brain Monoamine Interactions, $275,490 (Principal Investigator) |
| Funded at University of Kentucky, National Competition |
| 1982-1987 |
NIH: 1732 AG 00084-01A1, Multidisciplinary Training of Biogerontology,(Trainer: Dr. William Markesbery, Program Director). |
| 1981-1987 |
NIH: 2 RO1 AG 02867-04, Role of Suprachiasmatic Nuclear Serotonin in Female Reproductive Aging, $267,119 (Principal Investigator). |
| 1981-1984 |
NSF: BNS 81-03571, Role of Serotonin in Aging of the Female Reproductive System, $155,399 (Principal Investigator; declined in favor
of comparable NIH grant).
NIH: NS 17423, Neuroimmunomodulation, $160,000 Co-investigator with Drs. Roszman, Markesbery and Brooks).
Burroughs Wellcome Fund, Brain: ovarian interaction during preovulatory secretion of luteinizing hormone: Role of serotonin and progesterone (June 1981) $2,670. To work with Dr. Catherine
A. Wilson, Department of OB/GYN St. George's Hospital Medical School, Univ. of London, England.
Southern Regional Education Board, Age changes in serotonin metabolism in the suprachiasmatic nucleus (February 1981) $325. To work with Dr. Ralph L. Cooper, Center for the Study of
Aging, Duke University Medical Center, Durham, North Carolina.
Burroughs Wellcome Fund, Contribution of suprachiasmatic nuclear serotonin to the positive feedback effects of ovarian steroids on luteinizing hormone secretion (July-August 1983) $3,950.
To work with Dr. Catherine A. Wilson, Department of OB/GYN, St. Georges Hospital Medical School, University of London, England.
American Federation for Aging Research (AFAR), A Pacemaker for Aging in the Female Reproductive System (Jan-Dec 1984) $12,804 (Principal Investigator). |
| Local Competition |
| 11/3/80 |
New Faculty Grant - Serotonin and control of biologic time structure by the suprachiasmatic nuclei: Role in aging of the female reproductive
system, $18,600. |
| 1/2/81 |
Major Research Equipment Grant - Dynamics of Serotonin metabolism in the suprachiasmatic nuclei: Influence on female reproductive
dysfunction in aging rats, $13,600. |
| 2/4/81 |
Biomedical Research Support Grant, $3,350 - Role of serotonin in development of pituitary and mammary tumors in aging rats. |
| 5/4/81 |
McDowell Cancer Network Grant, $2,300 - Role of serotonin in development of pituitary and mammary tumors in aging rats. |
| Completed (at other universities) |
| 1978-1980 |
NIH Postdoctoral Research Grant F32 AG 05068 |
| 1977-1978 |
Public Health Service Postdoctoral Training Grant T32 AG 00029 |
| 1973-1976 |
USDA-ARS Cooperative Research Agreement with Clemson University, Contract #12-2427001 |
| 1973-1975 |
Clemson University Faculty Research Grant ($12,500). |
| |
| TEACHING EXPERIENCE |
| University of Kentucky Medical Center |
Department of Anatomy
(1) ANA 516 (Anatomy of the Nervous System: Neuroanatomy)
(2) ANA 529 (Concepts in Morphology)
(3) ANA 634 (Advanced Endocrinology)
Sanders-Brown Research Center on Aging
(1) PGY 630 (Special Topics in Physiology/Biology of Aging
(2) PCL 644 (Neuropharmacology) |
| University of California, Berkeley |
Department of Anatomy/Physiology
(1) Pharmacology 281 (Physiological Action of Drugs)
(2) Physiology 153 (Physiology of the Aging Process)
(3) Physiology 152 (Physiology of Human Development) |
Clemson University,
South Carolina |
Department of Zoology
(1) General Zoology
(2) General Biology
(3) Vertebrate Physiology
(4) General and Comparative Endocrinology
(5) Comparative Physiology
(6) Cell Physiology and Anatomy and Physiology |
| |
| UNIVERSITY SERVICE |
| Medical College of Pennsylvania |
(1) Graduate faculty: appointed to full status 9/1/85 |
| University of Kentucky Medical School |
(1) Committee on Aging
(2) Research Proposal Review Committee
(3) Seminar Chairman, Department of Anatomy, 1981-1984
(4) Graduate faculty; appointed to full status 10/6/80 |
| Clemson University |
University Level:
(1) Preprofessional Health Curricula Committee (member)
(2) Laboratory Animal Welfare Committee (member)
College Level:
(1) Admissions and Scholarship Committee
(2) Animal Physiology Program (Chairman) |
| STUDENTS |
| |
Medical College of Pennsylvania and Smith Kline and French Laboratories; one graduate student (Ph.D.) and one postdoctoral fellow. |
| |
University of Kentucky, one postdoctoral fellow (1982-1984).
1 graduate student (Ph.D.) |
| |
Clemson University, seven students for the degree Master of Science |
| |
| PROFESSIONAL AFFILIATIONS (Elected full member status): |
| |
- Society of Toxicology
- Endocrine Society
- American Association of Anatomists
- International Society for Neuroendocrinology
- Society of Sigma XI
|
| PROFESSIONAL LICENSES |
| |
Registered Pharmacist; PS0010079; Florida |
| RESEARCH INTERESTS |
| |
Role of the brain and endocrine system in organismal aging; Neuropharmacology and reproductive endocrinology; Neuropeptides & biogenic
amines |
| PATENTS |
| Patent Number U.S.S.N. |
Title |
| 898,523 |
Treatment of Hyperprolactinemia |
| 905,760 |
Diagnostic Procedure for Evaluating Growth Hormone
Secretion Deficiency |
| |
| SYMPOSIA ORGANIZED |
| |
- International Symposium on Growth Hormone II: Basic and Clinical Aspects, Tarpon Springs, Florida, 1992 (Serono Symposia; Chairpersons, R. F. Walker,
B.B. Bercu)
- International Symposium on Growth Hormone Releasing Secretagogues, St. Petersburg, Florida, 1994 (Serono Symposia; Chairpersons, R.F. Walker, B.B. Bercu)
- Workshop Conference on Growth Hormone Releasing Secretagogues, US Food and Drug Administration, Bethesda, Maryland, 1994 (Chairpersons, R.F. Walker,
B.B. Bercu)
- Second International Symposium on Growth Hormone Releasing Secretagogues, Tampa, Florida, 1997 (Chairpersons, R.F. Walker, B.B. Bercu)
- International Symposium on Endocrine and Molecular Interventions in Aging, Tampa, Florida, 1998 (Chairpersons, R.F. Walker , B.B. Bercu)
- Forum on Drug and Hormone Interventions in Aging, Tampa, Florida 1998 (Chairpersons, R.F. Walker, B.B. Bercu)
- International Symposium on the Endocrinology of Aging, Tempe, Arizona, 1999 (Serono Symposia; Chairpersons, R.F. Walker , B.B. Bercu)
- Third International Symposium on Growth Hormone Secretagogues, Keystone, Colorado, 2000 (Chairpersons, R.F. Walker, B.B. Bercu)
- Third International Symposium on the Endocrinology of Aging (Serono Symposia; October 17 – 20, 2001; Clearwater, FL, Chairpersons, R.F. Walker, B.B.
Bercu)
- Fourth International Symposium on Growth Hormone Secretagogues, November, 7- 11, 2002; Clearwater, FL, Chairpersons, R.F. Walker, B.B. Bercu)
- 3rd World Congress on the Aging male; Is Aging a Disease?, Berlin, Germany, February 7-11, 2002 (Serono Symposia satellite meeting, R.F. Walker, Chairman)
|
| |
| SUMMARY OF EMPLOYMENT EXPERIENCE |
| |
| 1999 – present |
CONSULTANT IN MEDICAL PHYSIOLOGY (Endocrinology/Pharmacology)
- Create clinical research programs for hormone replacement during aging.
- Function as liaison with the FDA to ensure compliance with federal guidelines for human subject research.
- Serve as regulatory officer and coordinator of client networks performing clinical trials, supervise CRA staff performing studies, statisticians performing
data reduction and analysis, create reports to IRB and FDA as required, publish data in peer-reviewed journals, maintain portfolios for each drug in development.
|
| 1996 - 1999 |
DIRECTOR, Division of Pharmaceutical Studies, and General Manager, Clinical Alliance for Research Education & Service,
Office of Research, University of South Florida, Tampa, FL
- Expand numbers of USF contracts from the pharmaceutical industry
- Enhance the economy of the State of Florida and the US in furthering the development of university-industry-government partnerships.
- Develop for USF CARES a solid reputation as a research contract organization that is capable of all levels of pharmaceutical drug/device development.
|
| 1995 - 1999 |
DIRECTOR, Division of Compliance Services, University of South Florida, Office of Research, Tampa, FL
- Develop, maintain and administer programs that assure compliance with federal and state guidelines related to the appropriate conduct of research.
- Managerial responsibilities include institutional review board (IRB), institutional animal care and use committee (IACUC), radioactive drug research
committee (RDRC), radiation safety program, biohazardous material control and diving safety programs
|
| 1991 - Present |
RESEARCH PROFESSOR, Department of Pediatrics, and Department of Biochemistry and Molecular Biology,
University of South Florida College of Medicine Tampa FL, and Division of Endocrinology, All Children's Hospital, St. Petersburg, FL 33706
- Perform basic research on neuroendocrine mechanisms of growth, development and aging. Support and maintain that research from public and private granting
agencies including the American Cancer Society, National Institutes of Health, Department of Defense, Pharmaceutical Industry (companies include Pfizer, Merck, Kaken/Wyeth Ayerst,
SmithKline Beecham, Serono Intl., BioNebraska, Dainippon, etc.)
- Manage laboratory of endocrinology, insuring successful progression of goals and time tables, making administrative and managerial decisions regarding
personnel commitments and expenditures, interpreting data, disseminating information at scientific meetings and other appropriate forums and being responsible for the prompt and
accurate preparation of progress reports and publication of data in peer-reviewed journals.
- Teach and supervise post-doctoral fellows and research associates while executing studies, entering new information into the database, implementing
new laboratory techniques, ordering supplies and maintaining supply records and radioisotope/narcotic licenses.
- Pharmacology Consultant; provide expertise pharmacology/toxicology/clinical issues to pharmaceutical companies relevant to development and registration
of new products, ie. from IND through NDA. Act as liaison between sponsor and FDA during drug licensing process. Provide expert opinions on drug-related issues involving legal disputes.
- Registered pharmacist; prepare and dispense medication pursuant to physicians orders for clinical studies
|
| 1985-1991 |
ASSOCIATE DIRECTOR, Department of Toxicology, SmithKline Beecham Pharmaceutical Company, King of Prussia,
PA 19406
- Project representative, providing pharmacology/toxicology input to Project Teams for compounds in development. Formulate pathology/toxicology element
of the development plan. Schedule and direct battery of toxicology studies in a timely fashion consistent with meeting deadlines for IND and NDA submissions. Make presentations
at FDA when needed to support progression of projects in clinical development. Insure that toxicological studies are appropriate to support international registration of compounds
in development.
- Study director, scheduling supervising and reporting results of general toxicology GLP and investigative studies.
- Manage Reproductive and Developmental Toxicology Division, insuring that schedules, designs and implementation of reproductive toxicological tests on
compounds in development are in compliance with FDA Segment I, II and III GLP guidelines.
- Generate appropriate reports and manuscripts in conjunction with safety studies.
- Head, Neuroendocrine Laboratory for investigative toxicology/pharmacology studies.
- Miscellaneous: Prepare section budget, supervise and evaluate employees, design and initiate basic research studies on pharmacological mechanisms of
actions loci of toxicity involving compounds in development.
|
| 1985-1988 |
RESEARCH PROFESSOR, Department of Pharmacology, Medical College of Pennsylvania, Philadelphia, PA
19128
- Principal investigator on 3 federally funded research projects that focused upon neuropharmacology and neuroendocrinology of monoamines.
- Budgetary responsibilities for approximately 1 million dollars in grant funds.
- Oversee, train, evaluate professional and technical research staff on my projects.
- Write continuation and competing renewals for federal and local research grants.
RESEARCH PROFESSOR, Department of Obstetrics and Gynecology, Medical College of Pennsylvania, Philadelphia PA 19128
- Collaborative research with clinical faculty providing correlative data from basic sciences projects for analysis of human responses
|
| 1980 - 1985 |
ASSOCIATE PROFESSOR (with tenure), Department of Anatomy, University of Kentucky Medical Center,
Lexington, KY 40536
- Teach neuroanatomy to medical and allied health students
- Serve on graduate faculty of College of medicine.
- Manage research programs, identify new sources of funding, expand support base from local and federal sources
- Publish reports in peer-reviewed journals and expand scientific reputation.
SENIOR SCIENTIST, Sanders-Brown Research Center on Aging, University of Kentucky Medical Center, Lexington, KY 40536
- Establish and expand public relations of the Aging Center with community physicians and lay persons.
- Develop research programs to probe neurological mechanisms of senescence.
- Present seminars and short courses on aging and its biological basis.
|
| 1977 - 1980 |
RESEARCH FELLOW, University of California, Department of Physiology/Anatomy, Berkeley, CA
- Basic research in neuropharmacology/neuroendocrinology
RESEARCH FELLOW, Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, NC
- Basic research in pharmacology of molecules affecting the reproductive system
|
| 1972 - 1977 |
ASSISTANT PROFESSOR TO ASSOCIATE PROFESSOR (with tenure), Department of Biology,
Clemson University, Clemson, SC
- Teach undergraduate and graduate courses in physiology/pharmacology
- Train graduate students
- Establish research program, acquire grants, develop teaching and research laboratories
- Participate in departmental and university service functions.
|
| |
| PUBLICATIONS: Peer-Reviewed Articles, Chapters and Books |
| 2002 |
Walker RF. Is Aging a Disease? A Review of the Serono Symposia Workshop held under the auspices of The 3rd World Congress on the Aging Male February 9, 2002,
Berlin Germany. The Aging Male5:1-23
Walker RF. Anti-Aging Medicine: Collecting Data or Collecting of Fees? Editorial. J
Anti-Aging Med. 5(3):234-246
Bercu BB, Walker RF. Relative Values of Recombinant GH and GH Secretagogues in Clinical Practice. The Endocrinologist 12(5):433-444.
Walker RF. Assessing Safety and Efficacy of Growth Hormone Replacement in Aging by Community Physicians. J Anti-Aging Med. 5(1): 41-55
Walker, RF, Bercu BB. Growth hormone therapy in aging: Is aging a treatable disease? J Anti-Aging Med 5(1):3-6.
|
| 2001 |
Walker RF, Bercu BB. Issues regarding the routine and long term use of growth hormone in anti-aging medicine: I. J Anti-Aging Med
4(4):279-300
Bercu BB, Walker RF. Preface to Winter 2001 and Spring 2002 Issues; Growth Hormone Therapy in Aging. J Anti-Aging Med 4(4):273-277.
Bercu BB, Walker RF. Editors; Growth Hormone Therapy in Aging. J Anti-Aging Med 4(4)
Walker, RF. Endocrinology of Aging (Book Review). Journal of Anti-aging Medicine 4 (1):67-70
Bercu BB, Walker, RF. Editors; Growth Hormone Secretagogues. Endocrine Vol. 14 (1). |
| 2000 |
Walker, RF, Bercu, BB. International Symposium on the Endocrinology of Aging: A Serono Symposium (editorial), J. Anti-Aging Medicine
3(3):259-261
Bercu BB, Walker, RF. International Symposium on the Endocrinology of Aging: A Serono Symposium (editorial), J. Anti-Aging Medicine 3(1):63-65 |
| 1999 |
Walker, R.F., Bercu, B.B. Use of growth hormone secretagogues for diagnosing and treating GH secretory deficiency in children and
aging men. In: Dieguez, C., Ghigo, E., Boghen, M, Casanueva, F.F. (editors), Growth Hormone Secretagogues: Basic Finding and Clinical Implications, Elsevier Science B.V., Amsterdam,
The Netherlands. |
| 1998 |
Bercu, B.B., Walker, R.F. Report on international symposium on endocrine and molecular interventions in aging. J. Anti-Aging Med
1:143-144
Walker, R.F., Bercu B.B. Aging Interventions: The Forest from the Trees (editorial), J. Anti-Aging Med 1:167 - 168
Walker, R.F., Bercu, B.B. Effectiveness of growth hormone (GH) secretagogues for diagnosing and treating GH secretory deficiency in aging men. J. Anti-Aging Med 1:219 - 225
Walker, R.F., Bercu, B.B. (guest editors). Special Papers on Endocrine Aspects of Aging. J. Anti-Aging Med: 1(3)
Bercu, B.B., Walker, R.F. (editors) Growth Hormone Secretagogues in Clinical Practice, Marcel Dekker, New York, NY.
Bercu, B.B., Walker, R.F. Evaluation of pituitary function using growth hormone secretagogues. In: Bercu, B.B., Walker, R.F. Growth Hormone Secretagogues in Clinical Practice. Marcel
Dekker, New York, NY, pp. 187-207. |
| 1997 |
Bercu, B. B., Walker, R. F. Growth hormone secretagogues in children with altered growth. Acta Paediatr Suppl 423:102-106.
Walker, R. F., Bercu B. B. Effects of a growth hormone releasing peptide-like nonpeptidyl growth hormone secretagogue on physiology and function in aged rats. In: Bercu BB, Walker,
RF (eds) Growth Hormone Secretagogues II. Marcel Dekker, New York N.Y. pp 1187 - 208.
Bercu, B. B., Walker, R. F. Evaluation of pituitary function using growth hormone secretagogues. In: Bercu BB, Walker RF (eds) Growth Hormone Secretagogues in Clinical Practice. Marcel
Dekker, New York, NY pp. 285-303.
Bercu, B.B., Walker, R.F. (Editors). Growth Hormone Secretagogues in Clinical Practice. Marcel Dekker, New York N.Y.
Bercu, B.B., Walker, R.F. Novel growth hormone secretagogues. The Endocrinologist 7: 51-64 |
| 1996 |
Bercu, B.B., Walker, R.F. (edited book) Serono Symposium Growth Hormone Secretagogues; with 138 figures. Springer-Verlag, New York,
pp 253-287.
Walker, R.F., Bercu, B.B. Animal models for evaluating xenobiotic growth hormone growth hormone secretagogue activity. In: Serono Symposium Growth Hormone Secretagogues, B.B. Bercu
and R.F. Walker, (eds) Springer-Verlag, New York, pp 253-287.
Bercu, B.B., Walker, R.F. A diagnostic test employing growth hormone secretagogues for evaluating pituitary function in the elderly. In: Serono Symposium Growth Hormone Secretagogues,
B.B. Bercu and R.F. Walker, (eds) Springer-Verlag, New York, pp 289-305.
Bercu, B.B., Walker, R.F. Evaluation of pituitary function in children using growth hormone secretagogues. J Ped Endo Metab 9:325-332 |
| 1995 |
Bercu, B.B., Heinze, H.J., Walker, R.F. Use of growth hormone in non-growth-hormone-deficient children: Physiologic, pharmacologic
and ethical issues. In: Serono Symposium GHRH, GH and IGF-1, Basic and Clinical Advances, M.R. Blackman, J. Roth, S.M. Harman and J.R. Shapiro (eds). Springer-Verlag, New York, pp 143-168.
Walker, R.F. Neuroendocrine correlates of female reproductive senescence. In: The Menopause: Comprehensive Management, 3rd Edition. B. A. Eskin (ed). McGraw Hill, Inc. New York, pp
229-256. |
| 1994 |
Walker, R.F., Yang, S-W., Masuda, R., Hu, C-S., Bercu, B.B. Effects of growth hormone releasing peptides on stimulated growth hormone secretion in old rats
In: Growth Hormone II: Basic and Clinical Aspects. Bercu, B.B., Walker, R. F. (eds). Springer-Verlag Inc: New York.
Walker, R.F., Engleman R.W., Pross, S. and Bercu B. B. Effects of growth hormone secretagogues on age-related changes in the rat immune system. Endocrine 2: 857-862.
Walker R.F., Eichler DC. and Bercu B.B. Inadequate pituitary stimulation: a possible cause of growth hormone insufficiency and hyperprolactinemia in aged rat. Endocrine 2:633-638.
Walker R. F., Ness G.C., Zhihong Z., Bercu B.B. Effects of stimulated growth hormone secretion on age-related changes in plasma cholesterol and hepatic low density lipoprotein messenger
RNA concentrations. Mechanisms of Aging and Development: 75:215-226.
Bercu B.B., Walker R.F. (Eds) Growth Hormone II: Basic and Clinical Aspects. Springer-Verlag Inc. New York. |
| 1992 |
Bercu, B.B., Yang, S-W., Masuda R. and Walker, R.F. Role of selected endogenous peptides in growth hormone releasing hexapeptide (GHRP-6)
activity: Analysis of GHRH, TRH and GnRH. Endocrinology 130:2579-2586.
Walker, R.F. and Cooper, R.L. Toxic effects of xenobiotics on the pituitary gland. In: Endocrine Toxicology, edited by C. Atterwill and J. Flack, Cambridge University Press, Cambridge,
pp 51-82.
Bercu, B.B., Yang, S-W., Masuda, R., Hu, C-S, and Walker, R.F. Effects of co-administered growth hormone (GH) releasing hormone and GH releasing hexapeptide on maladaptive aspects of
obesity in female Zucker rats. Endocrinology 131:2800-2804. |
| 1991 |
Walker, R.F. and Fishman, B.E. Influence of age on neuro-toxicity. In: Aging and Environmental Toxicology, R. L. Cooper, J.M. Goldman
and T.J. Harbin (eds.), John Hopkins University Press, Baltimore, pp 211-231.
Nelson, A.H., Walker, R.F., Codd, E.E. and Barone F.C. Intranasal activity of the growth hormone releasing peptide His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 in conscious dogs. Life Sciences 48:2283-2288.
Bercu, B.B., Weideman, C.A. and Walker, R.F. Sex differences in growth hormone secretion by rats administered growth hormone releasing hexapeptide (GHRP-6). Endocrinology 129:2592-2598.
Walker, R.F., Yang, S-W. and Bercu, B.B. Robust GH secretion in aging female rats coadministered growth hormone releasing hormone (GHRH) and GH releasing hexapeptide (GHRP-6). Life
Sciences 49:1499-1504. |
| 1990 |
Codd, E.E., Aloyo, V.J. and Walker, R.F. A non-opioid pattern characterizes inhibition of growth hormone releasing peptide binding
by dynorphin-related peptides. Neuropeptides 15:133-137.
Walker, R.F. and Cooper R.L. Endocrine physiology and reproductive senescence. In: B.A. Eskin (ed.) Menopause: Comprehensive Management, 3rd Ed., Yearbook Medical Publications, New
York, pp 211-270.
Walker, R.F., Codd, E.E., Barone, F.C., Nelson, A.H., Goodwin, T and Campbell, S.A. Oral activity of the growth hormone releasing peptide His-D-Trp-Ala-Trp-D-Phe-Lys-NH2in rats, dogs
and monkeys. Life Sciences 47:29-36. |
| 1989 |
Walker, R.F. and Aloyo, V.J. Modulation of norepinephrine and serotonin release by ACTH and aMSH in the pineal gland. Neuroendocrinol.
43:12-20.
Huffman, W.F., Callahan, J.F., Codd, E.E., Eggleston, B.S., Lemieux, C., Newlander, K.A., Schiller, P.W., Takata, D.T., and Walker, R.F. Mimics of secondary structural elements of peptides
and proteins. In: Synthetic Peptides: Approaches to Biological Problems. UCLA Symposium on Molecular and Cellular Biology, (Ed. J.Tam and T.Kaiser), Alan R. Liss, Inc. pp 257-266.
Bryan, W.M., Callahan, J.F., Codd, E.E., Lemieux, C. Moore, M.L., Schiller, P.W., Walker, R.F., Huffman, W.F.Cyclic enkephalin analogs containing a-amino-7-mercapto-4,7-cyclopentamethylenepropionic
acid at positions two or five. J. Med. Chem. 32:303-304.
Codd, E.E., Shu, A.Y.L., Walker, R.F. Binding of the growth hormone releasing hexapeptide, SK&F
110679 to specific hypothalamic and pituitary sites. Neuropharmacology 28:1139-1144.
Walker, R.F., Guerriero, F.J., Toscano, T.V. and Weideman, C.A. Relative cerebellar weight: A potential indicator of developmental neurotoxicity. Neurotoxicology and Teratology ll(3):251-255.
Wier, P.J., Guerriero, F.J., and Walker, R.F. Implementation of a primary screen for developmental toxicity. Fund Appl. Toxicol. 13:118-136
Aloyo, V.J., Lewis, M.E. and Walker, R.F. Opioid peptide mRNAs in the rat pineal. In: International Narcotic Research Conference (INRC), R. Wuirion, K. Jhamanda and C. Gianoulakis (eds.)
Alan R. Liss, New York, pp 235-238. |
| 1988 |
Huffman, W.F., Callahan, J.F., Eggleston, B.S., Newlander, K.S., Takata, D.T., Codd, E.E., Walker, R.F. Schiller, P.W., Lemieux, C., Wire, W.S., Burks, T.F.
Reverse turn mimics. In: Peptides: Chemistry and Biology: Proceedings of the tenth peptide symposium, (Ed. G.R. Marshall) ESCOM, Leiden, pp 105-108.
Jimenez, A. and Walker, R. F. Influence of serotonin (5HT) synthesis on circadian patterns of 5HT accumulation in the rat hypothalamus during development. Int. J. Devel. Neurosci.
6:203-209.
Aloyo, V.J. and Walker, R.F. Alpha-adrenergic control of serotonin release from rat pineal glands. Neuroendorinology 48:61-66.
Eskin, B.A., Trivedi, R.A., Weiderman, C.A. and Walker, R.F. Feedback disturbances revealed by analysis of serum reproductive hormones in women during aging. Am J. Gyn. Health 2:9-15
(Dec).
Walker, R. F., Weideman, C.A. and Wheeldon, E. B. Reduced disease in aged rats treated chronically with ibopamine, a catecholaminergic drug. Neurobiol. Aging 9:291-301.
Codd, E.E., Yellin, T. and Walker, R.F. Binding of growth hormone releasing hormones and enkephalin-deprived growth hormone releasing peptides to mu and delta opioid receptors in
rat forebrain. Neuropharmacology 27:1019-1025.
Walker, R.F., Schwartz, L.W. and Manson, J.M. Ovarian effects of an antiinflammatory-immunomodulatory drug in the rat. Toxicol. Appl. Pharm. 94(2):266-275.
Walker, R.F., Schwartz, L.W. and Torphy, T.J., Newton, J.F. and Manson, J.M. Ovarian effects of SK&F
86002-A2 in the rat: site of action. Toxicol. Appl. Pharm 94(2):276-275.
Walker, R.F., Guerriero, F. and Wier, P. Design of a primary screen for developmental neurotoxins. Toxicol. Indust. Health 5:231-245.
Jackson, J.C., Walker, R.F., Brooks, W.H., and Roszman, T.L. Specific uptake of serotonin by murine macrophages.Life Sciences 42:1641-1650.
Codd, E.E., McAllister, T.W. and Walker, R.F. Factors affecting serotonin uptake into human platelets. Psychopharmacology 95:180-184.
|
| 1987 |
Aloyo, V.J. and Walker, R.F. Noradrenergic stimulation of serotonin release from rat pineal glands, in vitro. Journal of Endocrinology
114:3-9.
Walker, R.F. and Aloyo, V.J. Molecular mechanisms controlling morepinephrine-mediated release of serotonin from rat pineal glands. In: Y.H. Ehrlich (eds.) Molecular Mechanisms of Neuronal
Responsivity, Advances in Experimental Medicine and Biology 221:223-236.
Codd, E.E. and Walker, R.F. Mu/delta opioid site selectively of some antidepressants. In: J. Holaday, A. Herz and P.Y. Law (eds.) NIDA Research Monograph, Progress in Opioid Research
75:351-354.
Navarro, H.A., Aloyo, V.J., Rush, M.E. and Walker, R.F. Serotonin pharmacodynamics in hypothalamic tissues from young and old female rats. Brain Research 421:291-296. |
| 1986 |
Walker, R.F., Sparks, D.L., Slevin, J. and Rush, M.E. Temporal effects of norepinephrine on pineal serotonin, in vitro. J. Pineal
Res. 3:30-40.
Walker, R.F. and Cooper, R.L. Endocrine physiology and reproductive senescence. In: B.A. Eskin (ed.) Menopause: Comprehensive Management, 2nd Ed., Yearbook Medical Publications, New
York pp. 209-235.
Walker, R.F. Age factors potentiating drug toxicity in the reproductive axis. Environ. Health Persp. 70:185-191. |
| 1985 |
Walker, R.F.and Jimenez, A. The serotoninergic system. In; Handbook of Methodologies for the Study of Neuro-endocrine System (R. W.
Steger and A. Johns, eds.) CRC Press, Inc., Boca Raton pp.109-154.
Walker, R.F. and Cooper, R.L. Synergistic effects of estrogen and serotonin-receptor agonists on the development of pituitary tumors in aging rats. Neurobiology of Aging 6:107-111.
Goldman, J.M., Walker, R.F. and Cooper, R.L. Aging in the rat hypothalamic-pituitary-ovarian axis: The involvement of biogenic amines in the loss of reproductive cyclicity. In: H.
Parvez and D. Gupta (eds.) Neuroendo-crinology of Hormone Transmitter Interaction, V.N.U. Science Press, Utrecht pp 127-152.
Jackson, J.C., Cross, R.J., Walker, R.F., Brooks, W.H., Markesbery, W.M. and Roszman, T.L. Neuroimmunomodulation: Influence of serotonin on the immune response. Immunology 54:505-512.
Humphries, L.L., Shirley, P., Codd, E.E. and Walker, R.F.Daily patterns of serotonin uptake in platelets from psychiatric patients and control volunteers. Biol Psychiatry 20:1073-1081.
Walker, R.F. and Aloyo, V.J. Norepinephrine stimulates serotonin secretion from rat pineal glands, in vitro. Brain Res. 343:188-189.
Walker, R.F. and Codd, E.E. Neuroimmunomodulatory interactions of norepinephrine and serotonin, J. Neuroimmunology 10:41-48. |
| 1984 |
Walker R.F and Jimenez, A. Quantitative relationship between light intensity and LH surges in ovariectomized rats treated with estrogen.
Biol. Reprod. 30:87-92.
Walker R.F. Impact of age-related changes in serotonin and norepinephrine metabolism on reproductive function in female rats. An analytical review. Neurobiol.Aging 5:121-139. |
| 1983 |
Walker, R.F. and Cooper, R.L. (Editors) Experimental and Clinical Interventions in Aging: Biomedical Explorations in Aging, Marcel
Dekker, New York (November).
Walker, R.F. Animal models for aging research. In Experimental and Clinical Interventions in Aging. (R.F.Walker and R.L. Cooper, eds.) Marcel Dekker, New York pp 67-84.
Walker, R.F. Serotonin-reinstatement of LH surges after positive feedback is lost in ovariectomized rats bearing subcutaneous estrogen-containing capsules. Journal of Endocrinology
98:7-17.
Walker, R.F. Quantatitive and temporal aspects of serotonin's facilitatory effect on LH surges in ovariectomized, estrogen-primed rats. Neuroendocrinology 36:468-474.
Walker, R.F. Reinstatement of cyclic reproductive function in aging female rats. In: Aging and Recovery of Function (S.Scheff, ed.) Plenum Press, New York 1983 Cooper, R.F. and Walker,
R.F. Radioenzymatic assays for neurotransmitters. In: Methods of Enzymology: Neuro-endocrine Peptides (P.M. Conn, ed.) Academic Press, New York, pp. 483-493
Walker, R.F. and Wilson, C.A. Changes in hypothalamic serotonin associated with amplication of LH surges by progesterone in rats. Neuroendocrinology 37:200-205.
Walker, R.F., Friedman, D.W. and Jimenez, A. A modified enzymatic-isotopic microassay for serotonin (5HT) using 5HT-N-acetyltransferase partially purified from Drosophila. Life Sciences
33:1915-1924. |
| 1982 |
Walker, R.F. and Timiras, P.S. Pacemaker insufficiency and the onset of aging. In: Cellular Pacemakers II (D. Carpenter, ed.) Wiley
Interscience, New York, pp. 396-425.
Walker, R.F., McCamant, S., and Timiras, P.S. Melatonin and the influence of the pineal gland on timing of the LH surge in rats. Neuroendocrinology 35:37-42.
Walker, R.F. Reinstatement of LH surges by serotonin neuroleptics in aging, constant estrus rats. Neurobiology of Aging 3:253-257.
Walker, R.F., Melatonin: serotonin interactions during termination of the LH surge in rats. In: The Pineal and Its Hormones (R. Reiter, ed.) Alan R. Liss, Inc., New York, pp 167-176. |
| 1981 |
Walker, R.F. Reproductive senescence and the dynamics of hypothalamic serotonin metabolism in the female rat. In: Brain Neurotransmitters
and Receptors in Aging and Age Related Disorders (T. Samorajski, S.J. Enna, and B. Beer,eds.) Raven Press, New York, pp. 95-105.
Walker, R.F. and Timiras, P.S. Serotonin in development of cyclic reproductive function. In: Serotonin: Current Aspects of Neurochemistry and Function, Adv. Exp. Biol. Med. 133 (B.
Haber, S. Gabay, M.R. Issidorides and S.G.A.Alivisatos, eds.) Plenum Press, New York, pp. 525-542. |
| 1980 |
Walker, R.F., Cooper, R.L. and Timiras, P.S. Constant estrus: Role of rostal hypothalmic monoamines in development of reproductive
dysfunction in aging rats. Endocrinology 107(1):249-255.
Walker, R.F. and Timiras, P.S. Loss of serotonin circadian rhythms in the pineal gland of androgenized female rats. Neuroendocrinology 31:265-269.
Eisenberg, E. and Walker, R.F. Physiological aspects of menopause: Clinical and experimental studies. In:Hormones in Development and Aging (P.S. Timiras and A.Vernadakis, eds.) Spectrum
Publ. New York, pp 517-537.
Walker, R.F. Serotonin circadian rhythm as a pacemaker for reproductive cycles in the female rat. In: Prog. Psychoneuroendocrinology (F. Brambilla, G. Racagni, and D. deWied, eds.)
Elsevier/ North Holland, Amsterdam, pp. 591-600.
Timiras, P.S., Segall, P.E. and Walker, R.F. Psychological aging in the central nervous system: Perspectives on "interventive" gerontology.
In: Aging- Its Chemistry. Proc. 3rd Arnold O. Beckman Conf. in Clin. Chem. (A. Dietz,ed.), Am Assn. Clin. Chem., Washington, DC pp.46-63
Walker, R.F. Serotonin neuroleptics change patterns of preovulatory secretion of luteinizing hormone in rats. Life Sciences 27(12):1063-1068
Cooper, R.L., Conn, M.P. and Walker, R.F. Characterization of the LH surge in middle-aged female rats. Biol. Reprod. 23:611-615. |
| 1979 |
Cooper, R.L., Brandt, S.J., Linnoila, M. and Walker R.F. Induced ovulation in aged female rats by L-Dopa implants into the medial
preoptic area. Neuroendocrinol, 28:234-240.
Cooper, R.L. and Walker, R.F. Potential therapeutic consequences of age-dependent changes in brain physiology. In: Experimental and Clinical Aspects of Pharmacological Intervention
in the CNS Aging Process, Interdiscipl. Topics Gerontol. Vol. 14 (W.Meier-Ruge & H. von Hahn, eds.) S. Karger, Basel, pp. 54-76. |
| 1978 |
Bethea, C.L. and Walker, R.F. Parietal eye-pineal gland interactions in the lizard, Sceloporus occidentalis. J. Herpetology 12(1):83-87.
Walker, R.F., McMahon, K.M. and Pivorun, E.B. Pineal gland structure and metabolism as affected by age and hypocaloric diet. Exp. Gerontol. 13:91-99.
Bethea, C.L. and Walker, R.F. Age-related changes in reproductive hormones and in Leydig cell responsivity in the male Fisher 344 rat. J. Gerontol. 34:21-27.
Walker, R.F. and Cooper, R.L. Influence of the thyroid gland on aging in the reproductive system of the female rat. Adv.Exp.Biol.Med. 113:111-126. |
| 1977 |
Lee, F., Walker, R.F. and Hatcher, J.S. Fine particles of cotton dust influence histamine release. Int. J. Occ. Health & Safety
46(4):42-45.
Walker, R.F. and Bethea, C.L. Gonadal function in underfed rats: I. Effect of pineal gland and constant light on maturation and fecundity. Biol. Reprod. 17:623-629.
Walker, R.F., and Frawley, L.S. Gonadal function in underfed rats. II. Effect of estrogen on plasma gonado-tropins after pinealectomy or constant light exposure. Biol. Reprod. 17:630-634. |
| 1975 |
Walker, R.F., Eidson, G.W. and Hatcher, J.D. Comparative responses of pulmonary leukocytes to cotton dust inhalation. Laboratory Invest.
33:28-34. |
| 1974 |
Frawley, L.S. and Walker, R.F. The effect of light on thyroid activity in bullfrog tadpoles. Gen. Comp. Endocrinol. 24:83-86. |
| 1973 |
Walker, R.F. Influence of subtrachael fat body depletion on thyroid function in the desert iguana. Comp. Biochem. Physiol. 44A:911-917.
Walker, R.F. Temperature effects on thyroid function in the lizard, Sceloporus cyanogenys. Gen. Comp. Endocrinol. 20(1):137-143. |
| 1971 |
Walker, R.F., and Thronebury, B. Lipid content of Verticillium albo-atrum. Phytochemistry 10:2979-2982. |
| 1970 |
Walker, R.F. and Whitford, S. Soil water absorption capabilities in selected anuran species. Herpetologica 26:411-418. |
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